Applying solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our research pursuits contain:
It absolutely was only while in the nineteen nineties however, when nanotechnology had Innovative to a degree where by solitary molecules may very well be manipulated, that the very first experimental products began to seem.
Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins
2007, 1st real-time detection of strand exchange in homologous recombination by RecA; discovery of the low persistence size of finishes of microtubules; and fixed the mechanism of biosensing with carbon nanotubes
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The coiled-coil on the human Rad50 DNA restore protein incorporates distinct segments of elevated adaptability
Due to the fact 2000 he moved to solitary-molecule biophysics and nanobiology, with study from DNA supercoiling studies of nucleosomes and DNA maintenance proteins to DNA translocation by nanopores. Just lately his analysis has focused on finding out cell division with bacteria on chip, though his supreme interest is within the way of noticing synthetic cells.
Atomic pressure microscopy reveals that vaccinia topoisomerase IB generates filaments on DNA inside a cooperative vogue
In 1993, as a younger and keen associate professor at Delft University of Know-how, I'd at first targeted the exploration efforts of my group on measuring the electrical conductance of an individual conducting-polymer molecule. Within just two years, we had developed a tool wherein just one wire of a phthalocyaninepolysiloxane polymer was linked concerning two intently spaced metal nanoelectrodes.
Resolving the stage measurement in condensin-driven DNA loop extrusion identifies ATP binding because the stage-producing procedure
An integrated microfluidic platform for quantifying drug permeation throughout biomimetic vesicle membranes
Several new phenomena were learned, and he and his analysis team proven a leading placement Within this industry of investigation. Dekker and his research team identified new physics of nanotubes as well as explored the feasibility of molecular electronics. In 1998, they ended up the very first to make a transistor depending on a single nanotube molecule.
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Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij satisfied enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond clever style in 2005. (nl)