Halfway by way of his occupation, Cees Dekker reinvented himself. After several years of hardcore physics, he shifted his concentrate to ‘nanobiology’ for the flip with the millennium. A term he coined himself, for a make a difference of actuality.
Human Rad51 filaments on double- and one-stranded DNA: correlating regular and irregular kinds with recombination operate.
Dynamics of initiation, termination and reinitiation of DNA translocation with the motor protein EcoR124I
Since 2000, Dekker has shifted the principle aim of his perform toward biophysics where he scientific studies the Houses of one biomolecules and cells using the resources of nanotechnology. This modification of industry was driven by his fascination for your impressive working of Organic molecular buildings, and by the lengthy-phrase point of view a large number of attention-grabbing discoveries may be anticipated On this subject.[five] Latest strains of investigate in his biophysics team are in the areas of:[six]
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The coiled-coil from the human Rad50 DNA repair protein has certain segments of increased overall flexibility
MATLAB codes for info processing are offered at . Julia codes employed for numerical simulation are available at .
Atomic drive microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in the cooperative vogue
‘You should not just think of the inquiries of tomorrow, but in addition look at the inquiries on the day soon after tomorrow’
1). The present–voltage curves showed important modulations with gate voltage, even at room temperature, which was per band bending in a ~0.6 eV bandgap semiconducting nanotube. These ceesdekker details also showed which the conductance might be modulated by six orders of magnitude by switching the gate voltage. The outcome of the function — a home-temperature transistor created from only one carbon nanotube molecule — had been released in Nature in Could 1998.
[14] In 2005 Dekker turned involved in Netherlands-huge discussions about Smart Structure, a movement that he has due to the fact clearly distanced himself from. Dekker advocates that science and religion are certainly not in opposition but may be harmonized.
Nanoscientist Cees Dekker can be an amiable and flamboyant male who appears A lot younger compared to the sixty two yrs he in fact is – trendy glasses, psychedelic shirt, partaking smile – although not one particular to waste time. He usually takes his time, but not more than required.
2008, first observation of protein-coated DNA translocation via nanopores; resolved the origin from the electrophoretic force on DNA in nanopores; discovered an important velocity maximize of microtubules in electric powered fields; uncovered an anomalous electro-hydrodynamic orientation of microtubules; and settled the origin of noise in carbon nanotubes in liquid
Example (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim on the pore is highlighted in pink, plus a 3D rendering of the motion of your DNA rod is displayed.